Cognitive simulation (CogSim) is an important and emerging workflow for HPC scientific exploration and scientific machine learning (SciML). One challenging workload for CogSim is the replacement of one component in a complex physical simulation with a fast, learned, surrogate model that is "inside" of the computational loop. The execution of this in-the-loop inference is particularly challenging because it requires frequent inference across multiple possible target models, can be on the simulation's critical path (latency bound), is subject to requests from multiple MPI ranks, and typically contains a small number of samples per request. In this paper we explore the use of large, dedicated Deep Learning / AI accelerators that are disaggregated from compute nodes for this CogSim workload. We compare the trade-offs of using these accelerators versus the node-local GPU accelerators on leadership-class HPC systems.