Quantum computing is an emerging paradigm that has shown great promise in accelerating large-scale scientific, optimization, and machine-learning workloads. With most quantum computing solutions being offered over the cloud, it has become imperative to protect confidential and proprietary quantum code from being accessed by untrusted and/or adversarial agents. In response to this challenge, we propose SPYCE, which is the first known solution to obfuscate quantum code and output to prevent the leaking of any confidential information over the cloud. SPYCE implements a lightweight, scalable, and effective solution based on the unique principles of quantum computing to achieve this task.