As large volumes of trajectory data accumulate, simplifying trajectories to reduce storage and querying costs is increasingly studied. Existing proposals face three main problems. First, they require numerous iterations to decide which GPS points to delete. Second, they focus only on the relationships between neighboring points (local information) while neglecting the overall structure (global information), reducing the global similarity between the simplified and original trajectories and making it difficult to maintain consistency in query results, especially for similarity-based queries. Finally, they fail to differentiate the importance of points with similar features, leading to suboptimal selection of points to retain the original trajectory information. We propose MLSimp, a novel Mutual Learning query-driven trajectory simplification framework that integrates two distinct models: GNN-TS, based on graph neural networks, and Diff-TS, based on diffusion models. GNN-TS evaluates the importance of a point according to its globality, capturing its correlation with the entire trajectory, and its uniqueness, capturing its differences from neighboring points. It also incorporates attention mechanisms in the GNN layers, enabling simultaneous data integration from all points within the same trajectory and refining representations, thus avoiding iterative processes. Diff-TS generates amplified signals to enable the retention of the most important points at low compression rates. Experiments involving eight baselines on three databases show that MLSimp reduces the simplification time by 42%--70% and improves query accuracy over simplified trajectories by up to 34.6%.