Cybersecurity attacks are a major and increasing burden to economic and social systems globally. Here we analyze the principles of security in different domains and demonstrate an architectural flaw in current cybersecurity. Cybersecurity is inherently weak because it is missing the ability to defend the overall system instead of individual computers. The current architecture enables all nodes in the computer network to communicate transparently with one another, so security would require protecting every computer in the network from all possible attacks. In contrast, other systems depend on system-wide protections. In providing conventional security, police patrol neighborhoods and the military secures borders, rather than defending each individual household. Likewise, in biology, the immune system provides security against viruses and bacteria using primarily action at the skin, membranes, and blood, rather than requiring each cell to defend itself. We propose applying these same principles to address the cybersecurity challenge. This will require: (a) Enabling pervasive distribution of self-propagating securityware and creating a developer community for such securityware, and (b) Modifying the protocols of internet routers to accommodate adaptive security software that would regulate internet traffic. The analysis of the immune system architecture provides many other principles that should be applied to cybersecurity. Among these principles is a careful interplay of detection and action that includes evolutionary improvement. However, achieving significant security gains by applying these principles depends strongly on remedying the underlying architectural limitations.