Bolivia’s President Rodrigo Paz faces a deepening crisis as widespread protests and blockades leave the political capital under siege less than six months after he took office.

Two weeks of road closures – spearheaded by the Bolivian Workers’ Central, COB, peasant unions and miners – have emptied markets in La Paz and depleted vital hospital oxygen reserves. The government reported that at least three people died after emergency vehicles were blocked from reaching medical centres.

On Monday, supporters of Bolivia’s influential ex-president Evo Morales clashed with police in the capital city as they joined multiple sectors demanding the resignation of the president, who lacks both a legislative majority and a robust political party to anchor his administration.

The unrest presents the biggest challenge yet for Paz, a business-friendly centrist who came to power six months ago as a wave of conservative electoral wins swept the region.

“Those seeking to destroy democracy will go to jail,” Paz warned on Friday, even as the blockades expanded to engulf nearly the entire country.

The COB began by demanding wage increases, while peasant unions demanded a steady supply of petrol. The miners, meanwhile, are negotiating separately for access to additional mining areas. Public school teachers are also holding separate talks regarding salary improvements.