Recent advances in natural-domain multi-modal large language models (MLLMs) have demonstrated effective spatial reasoning through visual and textual prompting. However, their direct transfer to remote sensing (RS) is hindered by heterogeneous sensing physics, diverse modalities, and unique spatial scales. Existing RS MLLMs are mainly limited to optical imagery and plain language interaction, preventing flexible and scalable real-world applications. In this article, EarthGPT-X is proposed, the first flexible spatial MLLM that unifies multi-source RS imagery comprehension and accomplishes both coarse-grained and fine-grained visual tasks under diverse visual prompts in a single framework. Distinct from prior models, EarthGPT-X introduces: 1) a dual-prompt mechanism combining text instructions with various visual prompts (i.e., point, box, and free-form) to mimic the versatility of referring in human life; 2) a comprehensive multi-source multi-level prompting dataset, the model advances beyond holistic image understanding to support hierarchical spatial reasoning, including scene-level understanding and fine-grained object attributes and relational analysis; 3) a cross-domain one-stage fusion training strategy, enabling efficient and consistent alignment across modalities and tasks. Extensive experiments demonstrate that EarthGPT-X substantially outperforms prior nature and RS MLLMs, establishing the first framework capable of multi-source, multi-task, and multi-level interpretation using visual prompting in RS scenarios.