Deep Neural Networks (DNNs) are vulnerable to adversarial attacks, which pose security challenges to hyperspectral image (HSI) classification based on DNNs. Numerous adversarial attack methods have been designed in the domain of natural images. However, different from natural images, HSIs contains high-dimensional rich spectral information, which presents new challenges for generating adversarial examples. Based on the specific characteristics of HSIs, this paper proposes a novel method to enhance the transferability of the adversarial examples for HSI classification using 3D structure-invariant transformation and weighted intermediate feature divergence. While keeping the HSIs structure invariant, the proposed method divides the image into blocks in both spatial and spectral dimensions. Then, various transformations are applied on each block to increase input diversity and mitigate the overfitting to substitute models. Moreover, a weighted intermediate feature divergence loss is also designed by leveraging the differences between the intermediate features of original and adversarial examples. It constrains the perturbation direction by enlarging the feature maps of the original examples, and assigns different weights to different feature channels to destroy the features that have a greater impact on HSI classification. Extensive experiments demonstrate that the adversarial examples generated by the proposed method achieve more effective adversarial transferability on three public HSI datasets. Furthermore, the method maintains robust attack performance even under defense strategies.