Multimodal Large Language Models (MLLMs) excel in vision-language tasks such as image captioning but remain prone to object hallucinations, where they describe objects that do not appear in the image. To mitigate this, we propose LISA, a Layer-wise Integration and Suppression Approach. LISA leverages the layer-wise functional roles in MLLMs: shallow layers provide visual grounding, middle layers encode semantics, and deep layers tend to amplify spurious signals. First, layer-wise spectral modulation stabilizes attention by suppressing over-amplified activations in deeper layers while preserving alignment cues in earlier layers. Second, token-level logits from selected layers are fused via anchor-based routing, with token-wise anchor selection and soft logit fusion enabling adaptive integration during decoding. LISA is fully plug-and-play and can be seamlessly integrated into existing MLLMs, including Qwen2.5-VL. Experiments on multiple benchmarks show that LISA reduces hallucinations by up to 53.6% in $\text{CHAIR}_\text{I}$ and improves POPE F1 by up to 5.1%, demonstrating strong generalization across models and tasks. Our code is available at https://github.com/zhlisa1010-eng/LISA.