Human-Object Interaction (HOI) detection aims to identify humans and objects within images and interpret their interactions. Existing HOI methods rely heavily on large datasets with manual annotations to learn interactions from visual cues. These annotations are labor-intensive to create, prone to inconsistency, and limit scalability to new domains and rare interactions. We argue that recent advances in Vision-Language Models (VLMs) offer untapped potential, particularly in enhancing interaction representation. While prior work has injected such potential and even proposed training-free methods, there remain key gaps. Consequently, we propose a novel training-free HOI detection framework for Dynamic Scoring with enhanced semantics (DYSCO) that effectively utilizes textual and visual interaction representations within a multimodal registry, enabling robust and nuanced interaction understanding. This registry incorporates a small set of visual cues and uses innovative interaction signatures to improve the semantic alignment of verbs, facilitating effective generalization to rare interactions. Additionally, we propose a unique multi-head attention mechanism that adaptively weights the contributions of the visual and textual features. Experimental results demonstrate that our DYSCO surpasses training-free state-of-the-art models and is competitive with training-based approaches, particularly excelling in rare interactions. Code is available at https://github.com/francescotonini/dysco.