This paper introduces FRAME (Fine-grained Recognition of Art-historical Metadata and Entities), a manually annotated dataset of art-historical image descriptions for Named Entity Recognition (NER) and Relation Extraction (RE). Descriptions were collected from museum catalogs, auction listings, open-access platforms, and scholarly databases, then filtered to ensure that each text focuses on a single artwork and contains explicit statements about its material, composition, or iconography. FRAME provides stand-off annotations in three layers: a metadata layer for object-level properties, a content layer for depicted subjects and motifs, and a co-reference layer linking repeated mentions. Across layers, entity spans are labeled with 37 types and connected by typed RE links between mentions. Entity types are aligned with Wikidata to support Named Entity Linking (NEL) and downstream knowledge-graph construction. The dataset is released as UIMA XMI Common Analysis Structure (CAS) files with accompanying images and bibliographic metadata, and can be used to benchmark and fine-tune NER and RE systems, including zero- and few-shot setups with Large Language Models (LLMs).