1.建立工程，比如Document，配置webconfig

<appSettings>        
        <add key="DefaultCulture" value="zh-cn" />
        <add key="CNCulture" value="zh-cn" />
        <add key="ENCulture" value="en-us" />
    </appSettings>

2.添加资源文件
右键添加新项目，选中Assembly Resource File,命名为strings.en-us.resx和strings.zh-cn.resx，然后配置如下
2.1  strings.en-us.resx

<?xml version="1.0" encoding="utf-8" ?>
<root>
    <xsd:schema id="root" xmlns="" xmlns:xsd="http://www.w3.org/2001/XMLSchema" xmlns:msdata="urn:schemas-microsoft-com:xml-msdata">
        <xsd:element name="root" msdata:IsDataSet="true">
            <xsd:complexType>
                <xsd:choice maxOccurs="unbounded">
                    <xsd:element name="data">
                        <xsd:complexType>
                            <xsd:sequence>
                                <xsd:element name="value" type="xsd:string" minOccurs="0" msdata:Ordinal="1" />
                                <xsd:element name="comment" type="xsd:string" minOccurs="0" msdata:Ordinal="2" />
                            </xsd:sequence>
                            <xsd:attribute name="name" type="xsd:string" />
                            <xsd:attribute name="type" type="xsd:string" />
                            <xsd:attribute name="mimetype" type="xsd:string" />
                        </xsd:complexType>
                    </xsd:element>
                    <xsd:element name="resheader">
                        <xsd:complexType>
                            <xsd:sequence>
                                <xsd:element name="value" type="xsd:string" minOccurs="0" msdata:Ordinal="1" />
                            </xsd:sequence>
                            <xsd:attribute name="name" type="xsd:string" use="required" />
                        </xsd:complexType>
                    </xsd:element>
                </xsd:choice>
            </xsd:complexType>
        </xsd:element>
    </xsd:schema>
    <resheader name="ResMimeType">
        <value>text/microsoft-resx</value>
    </resheader>
    <resheader name="Version">
        <value>1.0.0.0</value>
    </resheader>
    <resheader name="Reader">
        <value>System.Resources.ResXResourceReader, System.Windows.Forms, Version=1.0.5000.0, Culture=neutral, PublicKeyToken=b77a5c561934e089</value>
    </resheader>
    <resheader name="Writer">
        <value>System.Resources.ResXResourceWriter, System.Windows.Forms, Version=1.0.5000.0, Culture=neutral, PublicKeyToken=b77a5c561934e089</value>
    </resheader>
    <data name="LoginName">
        <value>Username</value>
    </data>
    <data name="Password">
        <value>Password</value>
    </data>    
</root>

2.2  strings.zh-cn.resx

<?xml version="1.0" encoding="utf-8" ?>
<root>
    <xsd:schema id="root" xmlns="" xmlns:xsd="http://www.w3.org/2001/XMLSchema" xmlns:msdata="urn:schemas-microsoft-com:xml-msdata">
        <xsd:element name="root" msdata:IsDataSet="true">
            <xsd:complexType>
                <xsd:choice maxOccurs="unbounded">
                    <xsd:element name="data">
                        <xsd:complexType>
                            <xsd:sequence>
                                <xsd:element name="value" type="xsd:string" minOccurs="0" msdata:Ordinal="1" />
                                <xsd:element name="comment" type="xsd:string" minOccurs="0" msdata:Ordinal="2" />
                            </xsd:sequence>
                            <xsd:attribute name="name" type="xsd:string" />
                            <xsd:attribute name="type" type="xsd:string" />
                            <xsd:attribute name="mimetype" type="xsd:string" />
                        </xsd:complexType>
                    </xsd:element>
                    <xsd:element name="resheader">
                        <xsd:complexType>
                            <xsd:sequence>
                                <xsd:element name="value" type="xsd:string" minOccurs="0" msdata:Ordinal="1" />
                            </xsd:sequence>
                            <xsd:attribute name="name" type="xsd:string" use="required" />
                        </xsd:complexType>
                    </xsd:element>
                </xsd:choice>
            </xsd:complexType>
        </xsd:element>
    </xsd:schema>
    <resheader name="ResMimeType">
        <value>text/microsoft-resx</value>
    </resheader>
    <resheader name="Version">
        <value>1.0.0.0</value>
    </resheader>
    <resheader name="Reader">
        <value>System.Resources.ResXResourceReader, System.Windows.Forms, Version=1.0.5000.0, Culture=neutral, PublicKeyToken=b77a5c561934e089</value>
    </resheader>
    <resheader name="Writer">
        <value>System.Resources.ResXResourceWriter, System.Windows.Forms, Version=1.0.5000.0, Culture=neutral, PublicKeyToken=b77a5c561934e089</value>
    </resheader>
    <data name="LoginName">
        <value>用户名</value>
    </data>
    <data name="Password">
        <value>密码</value>
    </data>    
</root>

3.在Global.asax写如下代码

protected void Application_BeginRequest(Object sender, EventArgs e)
        {
            try
            {
                if(Request.Cookies["CultureResource"]!=null)
                    Thread.CurrentThread.CurrentCulture=new CultureInfo(Request.Cookies["CultureResource"].Value);
                else   
                    Thread.CurrentThread.CurrentCulture=new CultureInfo(ConfigurationSettings.AppSettings["DefaultCulture"].ToString());
                Thread.CurrentThread.CurrentUICulture=Thread.CurrentThread.CurrentCulture;
            }
            catch(Exception)
            {
                Thread.CurrentThread.CurrentCulture=new CultureInfo(ConfigurationSettings.AppSettings["DefaultCulture"].ToString());
            }
        }

4.添加测试页面
4.1 html

<HTML>
    <HEAD>
        <title>Login</title>
        <meta name="GENERATOR" Content="Microsoft Visual Studio .NET 7.1">
        <meta name="CODE_LANGUAGE" Content="C#">
        <meta name="vs_defaultClientScript" content="JavaScript">
        <meta name="vs_targetSchema" content="http://schemas.microsoft.com/intellisense/ie5">
    </HEAD>
    <body>
        <form id="Form1" method="post" runat="server">
            <table align="center" cellSpacing="0" cellPadding="0" width="100%" border="0" height="100%">
                <colgroup>
                    <col width="20%">
                    </col>
                    <col width="60%">
                    </col>
                    <col width="20%">
                    </col>
                </colgroup>
                <tr>
                    <td></td>
                    <td valign="middle">
                        <TABLE id="Table1" align="center" cellSpacing="0" cellPadding="0" width="100%" border="0">
                            <colgroup>
                                <col width="50%">
                                </col>
                                <col width="50%">
                                </col>
                            </colgroup>
                            <TR>
                                <TD align="right">语言选择</TD>
                                <TD>
                                    <asp:Button id="Button1" runat="server" Text="中文"></asp:Button>
                                    <asp:Button id="Button2" runat="server" Text="英文"></asp:Button></TD>
                            </TR>
                            <TR>
                                <TD align="right">
                                    <asp:Label id="Label1" runat="server">Label</asp:Label></TD>
                                <TD>
                                    <asp:TextBox id="txtLoginName" runat="server" Width="100%"></asp:TextBox></TD>
                            </TR>
                            <TR>
                                <TD align="right">
                                    <asp:Label id="Label2" runat="server">Label</asp:Label></TD>
                                <TD>
                                    <asp:TextBox id="txtPassword" runat="server" Width="100%"></asp:TextBox></TD>
                            </TR>
                        </TABLE>
                    </td>
                    <TD></TD>
                </tr>
            </table>
        </form>
    </body>
</HTML>

4.2 cs代码

using System;
using System.Collections;
using System.ComponentModel;
using System.Data;
using System.Drawing;
using System.Web;
using System.Web.SessionState;
using System.Web.UI;
using System.Web.UI.WebControls;
using System.Web.UI.HtmlControls;
using System.Configuration;
using System.Threading;
using System.Resources;
using System.Globalization;
using System.Diagnostics;
using System.Reflection;
namespace Document
{
    /// <summary>
    /// Summary description for Login.
    /// </summary>
    public class Login : System.Web.UI.Page
    {        
        protected System.Web.UI.WebControls.TextBox txtLoginName;
        protected System.Web.UI.WebControls.TextBox txtPassword;
        protected System.Web.UI.WebControls.Button Button1;
        protected System.Web.UI.WebControls.Button Button2;
        protected System.Web.UI.WebControls.Label Label1;
        protected System.Web.UI.WebControls.Label Label2;
        private void Page_Load(object sender, System.EventArgs e)
        {
            Label1.Text = Resource("LoginName");
            Label2.Text = Resource("Password");
        }

        Web Form Designer generated code

        Resource

        private void Button2_Click(object sender, System.EventArgs e)
        {
            this.UpdateCultureCookie(ConfigurationSettings.AppSettings["ENCulture"].ToString());
            System.Web.UI.Page currentPage= (System.Web.UI.Page)this;
            Response.Redirect(currentPage.Request.Url.ToString());
        }

        private void Button1_Click(object sender, System.EventArgs e)
        {
            this.UpdateCultureCookie(ConfigurationSettings.AppSettings["CNCulture"].ToString());
            System.Web.UI.Page currentPage= (System.Web.UI.Page)this;
            Response.Redirect(currentPage.Request.Url.ToString());

        }
        private void UpdateCultureCookie(string culture)
        {
            if(Request.Cookies["CultureResource"] != null)
            {
                Response.Cookies["CultureResource"].Value = culture;
                Response.Cookies["CultureResource"].Expires = System.DateTime.Now.AddDays(30);
            }
            else
            {
                HttpCookie cultureCookie = new HttpCookie("CultureResource");
                cultureCookie.Value = culture;
                cultureCookie.Expires = System.DateTime.Now.AddDays(30);
                Response.Cookies.Add(cultureCookie);
            }
        }        
    }
}

5.源代码下载/Files/singlepine/Resource.rar
6.资源文件配置小工具使用XML读写删除功能来实现资源文件配置