惯性聚合 高效追踪和阅读你感兴趣的博客、新闻、科技资讯
阅读原文 在惯性聚合中打开

推荐订阅源

OSCHINA 社区最新新闻
OSCHINA 社区最新新闻
让小产品的独立变现更简单 - ezindie.com
让小产品的独立变现更简单 - ezindie.com
Hugging Face - Blog
Hugging Face - Blog
F
Fortinet All Blogs
G
Google Developers Blog
奇客Solidot–传递最新科技情报
奇客Solidot–传递最新科技情报
V
V2EX
Y
Y Combinator Blog
博客园_首页
Martin Fowler
Martin Fowler
博客园 - 司徒正美
MyScale Blog
MyScale Blog
宝玉的分享
宝玉的分享
B
Blog
有赞技术团队
有赞技术团队
A
About on SuperTechFans
量子位
钛媒体:引领未来商业与生活新知
钛媒体:引领未来商业与生活新知
Cyber Security Advisories - MS-ISAC
Cyber Security Advisories - MS-ISAC
酷 壳 – CoolShell
酷 壳 – CoolShell
Apple Machine Learning Research
Apple Machine Learning Research
M
MIT News - Artificial intelligence
阮一峰的网络日志
阮一峰的网络日志
Jina AI
Jina AI

Martin Fowler

I don't like LLMs Fragments: September 16 Nail your narrative Social Media Engagement: summer 2026 Fragments: September 8 Do you even need a presentation? Maybe We Shouldn't Be Reviewing All This Code An Accidental Blackboard Fragments: September 1 Making Your Data Ready for Agentic AI Fragments: August 24 Citizens Build, Agents Execute, Experts Govern Practitioner Voice Fragments: August 18 TDD inside the agent loop - theater or actual value? Fragments: August 4 The Conductor Developer The Economic Benefit of Refactoring The Orchestrator's Tax Why I’m Writing Rachel’s Ramblings Fragments: July 21 The Archaeologist’s Copilot DSLs Enable Reliable Use of LLMs Fragments: July 13 Experiences with local models for coding Viability of local models for coding Fragments: July 6 Building Reliable Agentic AI Systems Fragments: June 16 Fragments: June 2
bliki: Paracelsus Maxim
Martin Fowler · 2026-09-03 · via Martin Fowler

The difference between a medicine and a poison is dosage.

Often we talk about certain habits, in programming or life, are good or bad. But few things are simple binaries. Some vary with context: reading a book is a good thing sitting in my garden, but not while driving my car. But another variable is dosage: a little pain-killer salves my headache, but too much will kill me.

The importance of dosage was noticed by a 16th century Swiss physician called Paracelsus. His quote was originally in German “Alle Dinge sind Gift, und nichts ist ohne Gift; allein die Dosis macht, dass ein Ding kein Gift ist.” which (according to Wikipedia) translates as “All things are poison, and nothing is without poison; the dosage alone makes it so a thing is not a poison.” It's also known as “The dose makes the poison” or if you prefer your sayings in Latin “dosis sola facit venenum”.

In programming, global data is a good example of the Paracelsus Maxim (as I like to call it). A little global data, especially when immutable, can be a handy way of propagating information that may needed anywhere in a program, but it quickly becomes dangerous if there is a lot of it about.

This kind of thing crops up in lots of places. So when thinking about when things are good or bad, we should always ask “in what contexts” and “in what doses”?