Autism Spectrum Disorder (ASD) is the area where many researches enduring like Magnetic Resonance Imaging (MRI), called diffusion tensor imaging, Early Start Denver Model (ESDM) to provide an easier life for the people diagnosed. After years and years of combined funding sources from public and private funding, these researches show great promises in recent years. In this paper, we have tried to show a way how children with Down Syndrome Autism can learn through game therapy. These game therapies have shown an immense number of improvements among those children to learn alphabets along with developing their motor skills and memory challenges.