A bioinformatics researcher and a game design researcher walk into a lab... This paper shares two case-studies of a collaboration between a bioinformatics researcher who is developing a set of educational VR simulations for youth and a consultative game design researcher with a background in games User Research (GUR) techniques who assesses and iteratively improves the player experience in the simulations. By introducing games-based player engagement strategies, the two researchers improve the (re)playability of these VR simulations to encourage greater player engagement and retention.