The rise of autonomous driving technology has led to concerns about inactivity-induced fatigue. This paper explores Traditional Chinese Medicine (TCM) scents for mitigating. Two human-involved studies have been conducted in a high-fidelity driving simulator. Study 1 maps six prevalent TCM scents onto the arousal/valence circumplex to select proper candidates, i.e., argy wormwood (with the highest arousal) and tangerine peel (with the highest valence). Study 2 tests both scents in an auto-driving course. Statistics show both scents can improve driver alertness and reaction-time, but should be used in different ways: argy wormwood is suitable for short-term use due to its higher intensity but poor acceptance, while tangerine peel is ideal for long-term use due to its higher likeness. These findings provide insights for in-car fatigue mitigation to enhance driver safety and well-being. However, issues such as scent longevity as for aromatherapy and automatic fatigue prediction remain unresolved.