To enhance motion comfort in (automated) driving we present biomechanical models and demonstrate their ability to capture vibration transmission from seat to trunk and head. A computationally efficient full body model is presented, able to operate in real time while capturing translational and rotational motion of trunk and head with fore-aft, lateral and vertical seat motion. Sensory integration models are presented predicting motion perception and motion sickness accumulation using the head motion as predicted by biomechanical models.