The profound intertwining of digital interactions with traditional human interactions has spawned a novel mode of human interactions at both individual and population levels, carrying substantial ramifications for health. Digital mediation refers to the process by which digital interactions influence and facilitate human interactions. While digital mediations can bring benefits, they also pose potential health risks. We identify four levels where problems may arise: the medium itself, mediation architects, end users, and mediation orchestrators. Addressing the challenges associated with shaping digital mediation of human interactions for health requires strategies and future research. Shifting focus towards understanding the impact of digitally mediated interactions on health is crucial for advancing research, policy, and practice in this field.