We show that the volume of a convex body in $\mathbb{R}^{n}$ in the general membership oracle model can be computed to within relative error $\varepsilon$ using $\widetilde{O}(n^{3.5}ψ^{2} + n^3/\varepsilon^{2})$ oracle queries, where $ψ$ is the KLS constant. With the current bound of $ψ=\widetilde{O}(1)$, this gives an $\widetilde{O}(n^{3.5} + n^3/\varepsilon^{2})$ algorithm, improving on the Lovász-Vempala $\widetilde{O}(n^{4}/\varepsilon^{2})$ algorithm from 2003. The main new ingredient is an $\widetilde{O}(n^{3}ψ^{2})$ algorithm for isotropic transformation of a well-rounded convex body; we apply this iteratively to isotropicize a general convex body. Following this, we can apply the $\widetilde{O}(n^{3}/\varepsilon^{2})$ volume algorithm of Cousins and Vempala for well-rounded convex bodies. We also give an efficient implementation of the new algorithm for convex polytopes defined by $m$ inequalities in $\mathbb{R}^{n}$: polytope volume can be estimated in time $\widetilde{O}(mn^{c}/\varepsilon^{2})$ where $c<3.7$ depends on the current matrix multiplication exponent and improves on the previous best bound.