We revisit the classic combinatorial pattern matching problem of finding a longest common subsequence (LCS). For strings $x$ and $y$ of length $n$, a textbook algorithm solves LCS in time $O(n^2)$, but although much effort has been spent, no $O(n^{2-\varepsilon})$-time algorithm is known. Recent work indeed shows that such an algorithm would refute the Strong Exponential Time Hypothesis (SETH) [Abboud, Backurs, Vassilevska Williams + Bringmann, Künnemann FOCS'15]. Despite the quadratic-time barrier, for over 40 years an enduring scientific interest continued to produce fast algorithms for LCS and its variations. Particular attention was put into identifying and exploiting input parameters that yield strongly subquadratic time algorithms for special cases of interest, e.g., differential file comparison. This line of research was successfully pursued until 1990, at which time significant improvements came to a halt. In this paper, using the lens of fine-grained complexity, our goal is to (1) justify the lack of further improvements and (2) determine whether some special cases of LCS admit faster algorithms than currently known. To this end, we provide a systematic study of the multivariate complexity of LCS, taking into account all parameters previously discussed in the literature: the input size $n:=\max\{|x|,|y|\}$, the length of the shorter string $m:=\min\{|x|,|y|\}$, the length $L$ of an LCS of $x$ and $y$, the numbers of deletions $δ:= m-L$ and $Δ:= n-L$, the alphabet size, as well as the numbers of matching pairs $M$ and dominant pairs $d$. For any class of instances defined by fixing each parameter individually to a polynomial in terms of the input size, we prove a SETH-based lower bound matching one of three known algorithms. Specifically, we determine the optimal running time for LCS under SETH as $(n+\min\{d, δΔ, δm\})^{1\pm o(1)}$. [...]