We show that the two problems of computing the permanent of an $n\times n$ matrix of $\operatorname{poly}(n)$-bit integers and counting the number of Hamiltonian cycles in a directed $n$-vertex multigraph with $\operatorname{exp}(\operatorname{poly}(n))$ edges can be reduced to relatively few smaller instances of themselves. In effect we derive the first deterministic algorithms for these two problems that run in $o(2^n)$ time in the worst case. Classic $\operatorname{poly}(n)2^n$ time algorithms for the two problems have been known since the early 1960's. Our algorithms run in $2^{n-Ω(\sqrt{n/\log n})}$ time.