Given an undirected possibly weighted $n$-vertex graph $G=(V,E)$ and a set $\mathcal{P}\subseteq V^2$ of pairs, a subgraph $S=(V,E')$ is called a ${\cal P}$-pairwise $α$-spanner of $G$, if for every pair $(u,v)\in\mathcal{P}$ we have $d_S(u,v)\leqα\cdot d_G(u,v)$. The parameter $α$ is called the stretch of the spanner, and its size overhead is define as $\frac{|E'|}{|{\cal P}|}$. A surprising connection was recently discussed between the additive stretch of $(1+ε,β)$-spanners, to the hopbound of $(1+ε,β)$-hopsets. A long sequence of works showed that if the spanner/hopset has size $\approx n^{1+1/k}$ for some parameter $k\ge 1$, then $β\approx\left(\frac1ε\right)^{\log k}$. In this paper we establish a new connection to the size overhead of pairwise spanners. In particular, we show that if $|{\cal P}|\approx n^{1+1/k}$, then a ${\cal P}$-pairwise $(1+ε)$-spanner must have size at least $β\cdot |{\cal P}|$ with $β\approx\left(\frac1ε\right)^{\log k}$ (a near matching upper bound was recently shown in \cite{ES23}). We also extend the connection between pairwise spanners and hopsets to the large stretch regime, by showing nearly matching upper and lower bounds for ${\cal P}$-pairwise $α$-spanners. In particular, we show that if $|{\cal P}|\approx n^{1+1/k}$, then the size overhead is $β\approx\frac kα$. A source-wise spanner is a special type of pairwise spanner, for which ${\cal P}=A\times V$ for some $A\subseteq V$. A prioritized spanner is given also a ranking of the vertices $V=(v_1,\dots,v_n)$, and is required to provide improved stretch for pairs containing higher ranked vertices. By using a sequence of reductions, we improve on the state-of-the-art results for source-wise and prioritized spanners.