Consider a directed or an undirected graph with integral edge weights from the set [-W, W], that does not contain negative weight cycles. In this paper, we introduce a general framework for solving problems on such graphs using matrix multiplication. The framework is based on the usage of Baur-Strassen's theorem and of Strojohann's determinant algorithm. It allows us to give new and simple solutions to the following problems: * Finding Shortest Cycles -- We give a simple \tilde{O}(Wn^ω) time algorithm for finding shortest cycles in undirected and directed graphs. For directed graphs (and undirected graphs with non-negative weights) this matches the time bounds obtained in 2011 by Roditty and Vassilevska-Williams. On the other hand, no algorithm working in \tilde{O}(Wn^ω) time was previously known for undirected graphs with negative weights. Furthermore our algorithm for a given directed or undirected graph detects whether it contains a negative weight cycle within the same running time. * Computing Diameter and Radius -- We give a simple \tilde{O}(Wn^ω) time algorithm for computing a diameter and radius of an undirected or directed graphs. To the best of our knowledge no algorithm with this running time was known for undirected graphs with negative weights. * Finding Minimum Weight Perfect Matchings -- We present an \tilde{O}(Wn^ω) time algorithm for finding minimum weight perfect matchings in undirected graphs. This resolves an open problem posted by Sankowski in 2006, who presented such an algorithm but only in the case of bipartite graphs. In order to solve minimum weight perfect matching problem we develop a novel combinatorial interpretation of the dual solution which sheds new light on this problem. Such a combinatorial interpretation was not know previously, and is of independent interest.