Arslan showed that computing all-pairs Hamming distances is easily reducible to arithmetic 0-1 matrix multiplication (IPL 2018). We provide a reverse, linear-time reduction of arithmetic 0-1 matrix multiplication to computing all-pairs distances in a Hamming space. On the other hand, we present a fast randomized algorithm for approximate all-pairs distances in a Hamming space. By combining it with our reduction, we obtain also a fast randomized algorithm for approximate 0-1 matrix multiplication. Next, we present an output-sensitive randomized algorithm for a minimum spanning tree of a set of points in a generalized Hamming space, the lower is the cost of the minimum spanning tree the faster is our algorithm. Finally, we provide $(2+ε)$- approximation algorithms for the $\ell$-center clustering and minimum-diameter $\ell$-clustering problems in a Hamming space $\{0,1\}^d$ that are substantially faster than the known $2$-approximation ones when both $\ell$ and $d$ are super-logarithmic.