Sequences set is a mathematical model used in many applications. As the number of the sequences becomes larger, single sequence set model is not appropriate for the rapidly increasing problem sizes. For example, more and more text processing applications separate a single big text file into multiple files before processing. For these applications, the underline mathematical model is multiple sequences sets (MSS). Though there is increasing use of MSS, there is little research on how to process MSS efficiently. To process multiple sequences sets, sequences are first distributed to different sets, and then sequences for each set are processed. Deriving effective algorithm for MSS processing is both interesting and challenging. In this paper, we have defined the cost functions and performance ratio for analysis of the quality of synthesis sequences. Based on these, the problem of Process of Multiple Sequences Sets (PMSS) is formulated. We have first proposed two greedy algorithms for the PMSS problem, which are based on generalization of algorithms for single sequences set. Then based on the analysis of the characteristics of multiple sequences sets, we have proposed the Distribution and Deposition (DDA) algorithm and DDA* algorithm for PMSS problem. In DDA algorithm, the sequences are first distributed to multiple sets according to their alphabet contents; then sequences in each set are deposited by the deposition algorithm. The DDA* algorithm differs from the DDA algorithm in that the DDA* algorithm distributes sequences by clustering based on sequence profiles. Experiments show that DDA and DDA* always output results with smaller costs than other algorithms, and DDA* outperforms DDA in most instances. The DDA and DDA* algorithms are also efficient both in time and space.