This paper optimizes the configuration of large-scale data centers toward cost-effective, reliable and sustainable cloud supply chains. The problem involves placing incoming racks of servers within a data center to maximize demand coverage given space, power and cooling restrictions. We formulate an online integer optimization model to support rack placement decisions. We propose a tractable online sampling optimization (OSO) approach to multi-stage stochastic optimization, which approximates unknown parameters with a sample path and re-optimizes decisions dynamically. We prove that OSO achieves a strong competitive ratio in canonical online resource allocation problems and sublinear regret in the online batched bin packing problem. Theoretical and computational results show it can outperform mean-based certainty-equivalent resolving heuristics. Our algorithm has been packaged into a software solution deployed across Microsoft's data centers, contributing an interactive decision-making process at the human-machine interface. Using deployment data, econometric tests suggest that adoption of the solution has a negative and statistically significant impact on power stranding, estimated at 1-3 percentage point. At the scale of cloud computing, these improvements in data center performance result in significant cost savings and environmental benefits.