Representing a polygon using a set of simple shapes has numerous applications in different use-case scenarios. We consider the problem of covering the interior of a rectilinear polygon with holes by a set of area-weighted, axis-aligned rectangles such that the total weight of the rectangles in the cover is minimized. Already the unit-weight case is known to be NP-hard and the general problem has, to the best of our knowledge, not been studied experimentally before. We show a new basic property of optimal solutions of the weighted problem. This allows us to speed up existing algorithms for the unit-weight case, obtain an improved ILP formulation for both the weighted and unweighted problem, and develop several approximation algorithms and heuristics for the weighted case. All our algorithms are evaluated in a large experimental study on 186 837 polygons combined with six cost functions, which provides evidence that our algorithms are both fast and yield close-to-optimal solutions in practice.