A theorem of Ding, Oporowski, Oxley, and Vertigan implies that any sufficiently large twin-free graph contains a large matching, a co-matching, or a half-graph as a semi-induced subgraph. The sizes of these unavoidable patterns are measured by the matching index, co-matching index, and half-graph index of a graph. Consequently, graph classes can be organized into the eight classes determined by which of the three indices are bounded. We completely classify the parameterized complexity of Independent Set, Clique, and Dominating Set across all eight of these classes. For this purpose, we first derive multiple tractability and hardness results from the existing literature, and then proceed to fill the identified gaps. Among our novel results, we show that Independent Set is fixed-parameter tractable on every graph class where the half-graph and co-matching indices are simultaneously bounded. Conversely, we construct a graph class with bounded half-graph index (but unbounded co-matching index), for which the problem is W[1]-hard. For the W[1]-hard cases of our classification, we review the state of approximation algorithms. Here, we contribute an approximation algorithm for Independent Set on classes of bounded half-graph index.