This paper proposes a novel branch-and-bound(BMWVC) algorithm to exactly solve the minimum weight vertex cover problem (MWVC) in large graphs. The original contribution is several new graph reduction rules, allowing to reduce a graph G and the time needed to find a minimum weight vertex cover in G. Experiments on large graphs from real-world applications show that the reduction rules are effective and the resulting BMWVC algorithm outperforms relevant exact and heuristic MWVC algorithms.