We study the utility and limitations of using $k$-uniform hypergraphs $H = ([n], E)$ ($n \ge \mathrm{poly}(k)$) in the context of error reduction for randomized algorithms for decision problems with one- or two-sided error. Our error reduction idea is sampling a uniformly random hyperedge of $H$, and repeating the algorithm $k$ times using the hyperedge vertices as seeds. This is a general paradigm, which captures every pseudorandom method generating $k$ seeds without repetition. We show two results which imply a gap between the typical and the worst-case behavior of using $H$ for error-reduction. First, in the context of one-sided error reduction, if using a random hyperedge of $H$ decreases the error probability from $p$ to $p^k + ε$, then $H$ cannot have too few edges, i.e., $|E| = Ω(n k^{-1} ε^{-1})$. Thus, the number of random bits needed for reducing the error from $p$ to $p^k + ε$ cannot be reduced below $\lg n+\lg(ε^{-1})-\lg k+O(1)$. This is also true for hypergraphs of average uniformity $k$. Our result implies new lower bounds for dispersers and vertex-expanders. Second, if the vertex degrees are reasonably distributed, we show that in a $(1-o(1))$-fraction of the cases, choosing $k$ pseudorandom seeds using $H$ will reduce the error probability to at most $o(1)$ above the error probability of using $k$ IID seeds, for both algorithms with one- or two-sided error. Thus, despite our lower bound, for a $(1-o(1))$-fraction of randomized algorithms (and inputs) for decision problems, the advantage of using IID samples over samples obtained from a uniformly random edge of a reasonable hypergraph is negligible. A similar statement holds true for randomized algorithms with two-sided error.