We investigate the polynomial-time approximability of the multistage version of Min-Sum Set Cover ($\mathrm{DSSC}$), a natural and intriguing generalization of the classical List Update problem. In $\mathrm{DSSC}$, we maintain a sequence of permutations $(π^0, π^1, \ldots, π^T)$ on $n$ elements, based on a sequence of requests $(R^1, \ldots, R^T)$. We aim to minimize the total cost of updating $π^{t-1}$ to $π^{t}$, quantified by the Kendall tau distance $\mathrm{D}_{\mathrm{KT}}(π^{t-1}, π^t)$, plus the total cost of covering each request $R^t$ with the current permutation $π^t$, quantified by the position of the first element of $R^t$ in $π^t$. Using a reduction from Set Cover, we show that $\mathrm{DSSC}$ does not admit an $O(1)$-approximation, unless $\mathrm{P} = \mathrm{NP}$, and that any $o(\log n)$ (resp. $o(r)$) approximation to $\mathrm{DSSC}$ implies a sublogarithmic (resp. $o(r)$) approximation to Set Cover (resp. where each element appears at most $r$ times). Our main technical contribution is to show that $\mathrm{DSSC}$ can be approximated in polynomial-time within a factor of $O(\log^2 n)$ in general instances, by randomized rounding, and within a factor of $O(r^2)$, if all requests have cardinality at most $r$, by deterministic rounding.