We generalize the structure theorem of Robertson and Seymour for graphs excluding a fixed graph $H$ as a minor to graphs excluding $H$ as a topological subgraph. We prove that for a fixed $H$, every graph excluding $H$ as a topological subgraph has a tree decomposition where each part is either "almost embeddable" to a fixed surface or has bounded degree with the exception of a bounded number of vertices. Furthermore, we prove that such a decomposition is computable by an algorithm that is fixed-parameter tractable with parameter $|H|$. We present two algorithmic applications of our structure theorem. To illustrate the mechanics of a "typical" application of the structure theorem, we show that on graphs excluding $H$ as a topological subgraph, Partial Dominating Set (find $k$ vertices whose closed neighborhood has maximum size) can be solved in time $f(H,k)\cdot n^{O(1)}$ time. More significantly, we show that on graphs excluding $H$ as a topological subgraph, Graph Isomorphism can be solved in time $n^{f(H)}$. This result unifies and generalizes two previously known important polynomial-time solvable cases of Graph Isomorphism: bounded-degree graphs and $H$-minor free graphs. The proof of this result needs a generalization of our structure theorem to the context of invariant treelike decomposition.