We study the problem of computing an ensemble of multiple sums where the summands in each sum are indexed by subsets of size $p$ of an $n$-element ground set. More precisely, the task is to compute, for each subset of size $q$ of the ground set, the sum over the values of all subsets of size $p$ that are disjoint from the subset of size $q$. We present an arithmetic circuit that, without subtraction, solves the problem using $O((n^p+n^q)\log n)$ arithmetic gates, all monotone; for constant $p$, $q$ this is within the factor $\log n$ of the optimal. The circuit design is based on viewing the summation as a "set nucleation" task and using a tree-projection approach to implement the nucleation. Applications include improved algorithms for counting heaviest $k$-paths in a weighted graph, computing permanents of rectangular matrices, and dynamic feature selection in machine learning.