One of the most important algorithmic meta-theorems is a famous result by Courcelle, which states that any graph problem definable in monadic second-order logic with edge-set quantifications (i.e., MSO2 model-checking) is decidable in linear time on any class of graphs of bounded tree-width. Recently, Kreutzer and Tazari proved a corresponding complexity lower-bound - that MSO2 model-checking is not even in XP wrt. the formula size as parameter for graph classes that are subgraph-closed and whose tree-width is poly-logarithmically unbounded. Of course, this is not an unconditional result but holds modulo a certain complexity-theoretic assumption, namely, the Exponential Time Hypothesis (ETH). In this paper we present a closely related result. We show that even MSO1 model-checking with a fixed set of vertex labels, but without edge-set quantifications, is not in XP wrt. the formula size as parameter for graph classes which are subgraph-closed and whose tree-width is poly-logarithmically unbounded unless the non-uniform ETH fails. In comparison to Kreutzer and Tazari; $(1)$ we use a stronger prerequisite, namely non-uniform instead of uniform ETH, to avoid the effectiveness assumption and the construction of certain obstructions used in their proofs; and $(2)$ we assume a different set of problems to be efficiently decidable, namely MSO1-definable properties on vertex labeled graphs instead of MSO2-definable properties on unlabeled graphs. Our result has an interesting consequence in the realm of digraph width measures: Strengthening the recent result, we show that no subdigraph-monotone measure can be "algorithmically useful", unless it is within a poly-logarithmic factor of undirected tree-width.