The independence gap of a graph was introduced by Ekim et al. (2018) as a measure of how far a graph is from being well-covered. It is defined as the difference between the maximum and minimum size of a maximal independent set. We investigate the independence gap of a graph from structural and algorithmic points of view, with a focus on classes of perfect graphs. Generalizing results on well-covered graphs due to Dean and Zito (1994) and Hujdurović et al. (2018), we express the independence gap of a perfect graph in terms of clique partitions and use this characterization to develop a polynomial-time algorithm for recognizing graphs of constant independence gap in any class of perfect graphs of bounded clique number. Next, we introduce a hereditary variant of the parameter, which we call hereditary independence gap and which measures the maximum independence gap over all induced subgraphs of the graph. We show that determining whether a given graph has hereditary independence gap at most $k$ is polynomial-time solvable if $k$ is fixed and co-NP-complete if $k$ is part of input. We also investigate the complexity of the independent set problem in graph classes related to independence gap, showing that the problem is NP-complete in the class of graphs of independence gap at most one and polynomial-time solvable in any class of graphs with bounded hereditary independence gap. Combined with some known results on claw-free graphs, our results imply that the independent domination problem is solvable in polynomial time in the class of $\{$claw, 2$P_3\}$-free graphs.