We establish new hardness results for decision tree optimization problems, adding to a line of work that dates back to Hyafil and Rivest in 1976. We prove, under randomized ETH, superpolynomial lower bounds for two basic problems: given an explicit representation of a function $f$ and a generator for a distribution $\mathcal{D}$, construct a small decision tree approximator for $f$ under $\mathcal{D}$, and decide if there is a small decision tree approximator for $f$ under $\mathcal{D}$. Our results imply new lower bounds for distribution-free PAC learning and testing of decision trees, settings in which the algorithm only has restricted access to $f$ and $\mathcal{D}$. Specifically, we show: $n$-variable size-$s$ decision trees cannot be properly PAC learned in time $n^{\tilde{O}(\log\log s)}$, and depth-$d$ decision trees cannot be tested in time $\exp(d^{\,O(1)})$. For learning, the previous best lower bound only ruled out $\text{poly}(n)$-time algorithms (Alekhnovich, Braverman, Feldman, Klivans, and Pitassi, 2009). For testing, recent work gives similar though incomparable bounds in the setting where $f$ is random and $\mathcal{D}$ is nonexplicit (Blais, Ferreira Pinto Jr., and Harms, 2021). Assuming a plausible conjecture on the hardness of Set-Cover, we show our lower bound for learning decision trees can be improved to $n^{Ω(\log s)}$, matching the best known upper bound of $n^{O(\log s)}$ due to Ehrenfeucht and Haussler (1989). We obtain our results within a unified framework that leverages recent progress in two lines of work: the inapproximability of Set-Cover and XOR lemmas for query complexity. Our framework is versatile and yields results for related concept classes such as juntas and DNF formulas.