We give cell-probe bounds for the computation of edit distance, Hamming distance, convolution and longest common subsequence in a stream. In this model, a fixed string of $n$ symbols is given and one $δ$-bit symbol arrives at a time in a stream. After each symbol arrives, the distance between the fixed string and a suffix of most recent symbols of the stream is reported. The cell-probe model is perhaps the strongest model of computation for showing data structure lower bounds, subsuming in particular the popular word-RAM model. * We first give an $Ω((δ\log n)/(w+\log\log n))$ lower bound for the time to give each output for both online Hamming distance and convolution, where $w$ is the word size. This bound relies on a new encoding scheme and for the first time holds even when $w$ is as small as a single bit. * We then consider the online edit distance and longest common subsequence problems in the bit-probe model ($w=1$) with a constant sized input alphabet. We give a lower bound of $Ω(\sqrt{\log n}/(\log\log n)^{3/2})$ which applies for both problems. This second set of results relies both on our new encoding scheme as well as a carefully constructed hard distribution. * Finally, for the online edit distance problem we show that there is an $O((\log n)^2/w)$ upper bound in the cell-probe model. This bound gives a contrast to our new lower bound and also establishes an exponential gap between the known cell-probe and RAM model complexities.