MLB probable pitchers for May 21, 2026. See all starting matchups, game times, odds, and strikeout props for today’s slate.
Looking for today’s MLB probable pitchers? Here’s the full list of starting pitcher matchups for May 21, 2026, including game times and embedded widgets with odds, strikeout props, and team trends. You can also find the latest odds and player props for today’s games on DraftKings Sportsbook.
Wednesday’s slate features a lighter schedule, highlighted by Spencer Strider facing Sandy Alcantara in Miami, Casey Mize continuing his breakout season for Detroit, and Jose Soriano looking to rebound after a rough recent stretch for the Angels.
Cantillo has been very strong against left-handed bats, with a .263 wOBA and a 3.19 FIP. Mize has been fantastic through seven starts, posting a 2.43 ERA with an xERA of 2.98 and a 9.4 K/9.
Ashcraft hasn’t allowed more than two earned runs in seven of his nine starts this season. Against lefties, May has a .397 wOBA with a 4.96 FIP and three of the four home runs he’s allowed.
In his prior start against the Mets, Cavalli allowed two runs on eight hits and 10 strikeouts through six innings.
Strider has been excellent since his return, posting a 2.45 ERA with a 2.89 xERA and a K/9 of 11 through 14.2 innings. Alcantara has thrown at least six innings in eight of his 10 starts.
Through two starts, Rodon has allowed six runs on five hits with 10 strikeouts and eight walks through 8.0 innings.
While Severino still has an unsightly 5.1 BB/9, but he’s limited the walks as of late. He’s only issued eight through 16.1 innings in the month of May. After allowing just one single run in his first six starts, Soriano has been tagged for 15 runs in his last four.
Sugano has a 4.02 ERA with an xERA of 7.25 and a 5.50 FIP. Rodriguez currently has the lowest K/9 of his career at 6.5 through 53.1 innings.
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