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Minnesota Twins vs. Milwaukee Brewers prediction, pick fo...
Dan Johnson · 2026-05-16 · via DraftKings Network

Dan Johnson takes you through his preview, prediction, and best bet for today’s baseball game between the Minnesota Twins and the Milwaukee Brewers.

Milwaukee comes into Target Field at 24-17 with real traction after a 5-1 homestand, carrying a lineup that has been more complete than flashy and a pitching staff that has kept the Brewers steady through changing rotation pieces. Minnesota is 20-24 and playing better baseball than its record suggests, with four wins in five games and a home setting that should play warm with the ball carrying in mid-May air. The lineup absences matter immediately: Christian Yelich’s back issue takes away one of Milwaukee’s best left-handed bats, while Byron Buxton’s hip flexor soreness removes Minnesota’s loudest power-speed threat. That leaves a game with a narrow market, a clear starting-pitcher advantage for the Twins, and a late-game structure that still gives Milwaukee a very real path. Below is my preview, prediction, and pick for today’s baseball game between the Minnesota Twins and the Milwaukee Brewers.

Here’s how I’ll play it. I’ll be pumping out these predictions for individual games all season, with plenty of coverage here on DraftKings Network. Follow my handle @dansby_edits for more betting plays.

Twins vs. Brewers prediction, preview

Joe Ryan is the reason Minnesota has a clean early-game argument. He brings a 3.43 ERA, 1.03 WHIP, 3.04 FIP and 3.90 xFIP through 44.2 innings, with a 24.9% strikeout rate, 7.2% walk rate, 17.7% K-BB rate and only 0.60 HR/9. His first trip through the order has been especially sharp, holding hitters to a .164/.243/.313 slash and .254 wOBA, so Milwaukee’s first look may be more grind than ambush. The Brewers’ opening is that Ryan’s contact profile is a little louder than the surface line: 90.0 mph average exit velocity allowed, 40.8% hard-hit rate, 10.0% barrel rate and a second-time-through jump to a .270/.347/.397 slash with a .335 wOBA. Coleman Crow gives Milwaukee a shakier starting point, even after a clean first MLB start with a 3.38 ERA and 0.94 WHIP in 5.1 innings. His Triple-A line—4.70 ERA, 4.39 FIP, 4.01 xFIP, 10.2% walk rate and 1.17 HR/9—keeps the Twins’ early scoring path alive if his cutter/curve/four-seam/sinker mix leaks over the plate.

The Brewers’ lineup has enough spread-out pressure to survive Yelich sitting. Brice Turang has become a genuine top-order problem at .298/.422/.511 with a .411 wOBA, 166 wRC+, .213 ISO, 17.7% walk rate, eight steals, 91.9 mph average exit velocity, 47.7% hard-hit rate and .410 xwOBA. William Contreras gives Milwaukee a second stabilizer with a .281/.362/.392 line, .338 wOBA, 116 wRC+, 10.9% walk rate and 11.5% strikeout rate, while Jake Bauers supplies the left-handed damage lane with six homers, a .205 ISO, .355 wOBA, 127 wRC+, 92-plus mph average exit velocity and a hard-hit rate above 52%. Andrew Vaughn has been swinging it well lately, going 6-for-16 with two doubles, one homer, five RBI, four walks and a 1.211 OPS over the last week, and Garrett Mitchell’s 91.5 mph average exit velocity, 50.0% hard-hit rate and 11.3% barrel rate give Milwaukee another weather-aided slug path even with the strikeout risk.

Minnesota’s best answer is Ryan Jeffers, the game’s clearest single-swing danger at .294/.409/.532 with six homers, a .413 wOBA, 163 wRC+, .239 ISO, 16.3% barrel rate and a 1.382 OPS over his recent eight-day surge. Austin Martin can set the table at .333/.454/.429 with a .403 wOBA, 156 wRC+, 16.9% walk rate and seven steals, and Kody Clemens has a recent 1.095 OPS push, but Josh Bell’s 15 strikeouts in 26 recent at-bats, Royce Lewis’ .161/.269/.290 season line and James Outman’s .222 wOBA leave the Twins more dependent on a few bats landing their loudest contact.

Brewers vs. Twins pick, best bet

The cleanest case against Milwaukee is that Ryan can simply be the best player in the first six innings. His fastball-heavy shape can miss enough bats to cover the occasional barrel, Crow’s minor-league walk profile could force the Brewers into middle relief by the fourth or fifth, and the warm Target Field weather gives Jeffers, Lewis or Bell enough carry to flip the game on one mistake. That concern is real because Milwaukee’s bullpen has some recent workload on Aaron Ashby, DL Hall, Abner Uribe and Trevor Megill, so a short Crow start would make the road dugout manage aggressively. The pushback is that Minnesota’s own late-game group remains harder to trust across the full season, with several key relievers carrying inflated ERA/FIP profiles, and the Twins’ Buxton-less lineup asks Jeffers and the on-base bats to do a lot of the heavy lifting. Milwaukee can lose the first-starting-pitcher comparison and still own the better full-game shape if the lineup extends Ryan’s pitch count and gets even two or three innings against the Minnesota bullpen.

That is why the full-game Milwaukee moneyline is the better bet shape than the flashier alternatives. Brewers team total over 4.5 at plus money has appeal because Ryan has second-time-through contact risk and Minnesota’s bullpen can leak traffic, but it asks for a fuller offensive payoff against a starter with a 3.04 FIP and only three homers allowed. Brewers run line offers a better payout and fits Milwaukee’s deeper roster, yet Ryan’s quality and the pick’em pricing make one-run risk too obvious. The first-five over 4.5 has weather and Crow volatility behind it, but Yelich and Buxton both sitting trims the early thunder on each side. Twins first-five -0.5 is the pure starter-gap play, though it leans heavily on a thinned Minnesota lineup cashing Crow’s mistakes before Milwaukee gets into the part of the game that favors its depth. Brewers ML at -105 to -109 is the cleaner lane because it respects Ryan, absorbs Crow volatility better than a first-five bet, and lets Milwaukee’s lineup depth and bullpen structure matter over nine innings.

Best bet: Brewers ML -105 to -109, playable to -115. Brewers team total over 4.5 at plus money is the more aggressive alternate, but the moneyline is the stronger main position because it gives Ryan proper respect while still backing the deeper full-game team. The way this loses is Ryan controlling the first two trips through Milwaukee’s order while Jeffers or Lewis turns one Crow mistake into early separation, but the Brewers have more viable scoring routes and the steadier ninth-inning profile.

Final score projection: Brewers 5, Twins 4.

Best bet: Brewers (-105) at Twins

Tail it with me in the DKN Betting Group here!