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San Francisco Giants vs. Atlanta Braves prediction, pick ...
Brendan O'Sullivan · 2026-06-27 · via DraftKings Network

Brendan O’Sullivan dives into his pick and prediction for the San Francisco Giants vs. Atlanta Braves game on Friday, June 26.

The Giants and Braves play the first game of their three-game series on Friday, June 26.

Atlanta is a -120 moneyline favorite, while San Francisco is -101 on DraftKings Sportsbook. The game total is set at over/under 8.5 runs.

Let’s get into a pick and prediction for this Giants vs. Braves game.

Giants vs. Braves prediction, preview

The Braves lead the NL East by four games entering their weekend series against the struggling Giants. San Francisco is 33-47 and in fourth place in the NL West. It’s been a miserable season and it’s only about halfway through. The team has a -54 run differential, and would need a miracle to make a run at the postseason this year.

Meanwhile, Atlanta bounced back after a disappointing 2025 season. The team is 48-31 with a +92 run differential, which ranks third in the National League and fourth in the majors. Even with Ronald Acuna Jr. hurt again, the lineup is a top-10 run-scoring unit with a top-10 team batting average.

Although the teams are quite lopsided in record and run differential, the moneyline is tight thanks to injuries and tonight’s openers/starters.

Trevor McDonald is making his 10th start for the Giants this year and 12th overall. He doesn’t have much history to analyze, but his 2026 campaign hasn’t been great. He has a 4.93 ERA through 45.2 innings and nine starts. His last two outings lasted 3.0 and 3.2 innings, though he did pitch seven frames in his season debut on May 4.

Reynaldo Lopez is Atlanta’s opener, serving largely as a reliever this season. He was a full-time starter in 2024 with the Braves, so this isn’t an unfamiliar role. That said, he’s been conditioned to pitch fewer innings out of the bullpen, capping out at three frames in his last outing.

The Braves have the top-ranked bullpen ERA in the majors, so a short start from Lopez isn’t a worry. The unit has a 2.85 ERA, while the second best (San Diego) has a 3.12.

Giants vs. Braves Pick, Best Bet

Even though the Braves have lost four straight games, I’m confident they bounce back against the Giants. It’s been an ugly road trip, but that changes on Friday.

Best Bet: Atlanta Braves ML (-120)