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Chicago White Sox vs. Cleveland Guardians prediction, pick for MLB on Wednesday 6/24/26
Dan Johnson · 2026-06-25 · via DraftKings Network

Dan Johnson takes you through his preview, prediction, and best bet for today’s baseball game between the Chicago White Sox and the Cleveland Guardians.

Wednesday afternoon brings a small June division fight with a strange amount of heat. Cleveland arrives at Rate Field at 41-39, sliding through a three-game skid and trying to salvage the series. Chicago is 41-37, sitting atop the AL Central, and already has the first two games tucked away. Monday ended with Sam Antonacci’s two-run walk-off single. Tuesday turned on Miguel Vargas’ 17th homer in a 2-1 win. The White Sox have won 22 of their last 26 home games, and Cleveland is trying to fight through a lineup missing José Ramírez, Chase DeLauter, and Angel Martinez. Below is my preview, prediction, and pick for today’s baseball game between the Chicago White Sox and the Cleveland Guardians.

Here’s how I’ll play it. I’ll be pumping out these predictions for individual games all season, with plenty of coverage here on DraftKings Network. Follow my handle @dansby_edits for more betting plays.

White Sox vs. Guardians prediction, preview

Tanner Bibee gives Cleveland the cleaner starting profile, but this is not a comfortable road-favorite setup. Bibee owns a 4.03 ERA, 1.18 WHIP, 78 strikeouts, and 28 walks across 89.1 innings. The deeper contact profile carries danger: 1.61 HR/9, 4.66 FIP, 38.7% ground-ball rate, 90.8 mph average exit velocity, 45.5% hard-hit rate, and a 10.2% barrel rate allowed. Chicago’s pitching plan is messier, with Chris Murphy opening and Erick Fedde expected in bulk relief. Murphy brings walk volatility, while Fedde carries a 4.46 ERA, 5.59 FIP, 15.6% strikeout rate, 8.8% walk rate, 1.78 HR/9, and 1.39 WHIP. That keeps Cleveland alive, but it does not erase Chicago’s lineup edge.

Chicago’s best healthy bats fit this matchup better than the price suggests. Vargas has 17 homers, 10 steals, a .233 ISO, .237/.350/.470 slash, .358 wOBA, 128 wRC+, 44.7% hard-hit rate, and 14.2% barrel rate. Colson Montgomery adds 20 homers, a .266 ISO, .219/.312/.485 slash, 117 wRC+, 46.2% hard-hit rate, and 14.5% barrel rate. Antonacci brings the table-setting pulse with a .287/.386/.416 line, 11 steals, 129 wRC+, and only a 15.5% strikeout rate. Peters has given Chicago another stable left-handed bat at .289/.350/.443 with a 121 wRC+. Kyle Teel’s return also gives the middle of the order more shape than Cleveland wants to see.

The Guardians still have a path, and it starts with Travis Bazzana. He has been Cleveland’s best available bat, carrying a .268/.365/.458 line, seven homers, 12 steals, .190 ISO, .361 wOBA, and 131 wRC+. Brayan Rocchio gives the lineup contact at .271/.346/.392 with 12 steals and a 109 wRC+. Kyle Manzardo brings left-handed pop with nine homers and a 12.5% barrel rate, though his 31.9% strikeout rate gives Fedde and Murphy a chase path. Cleveland also owns the cleaner late-game bullpen shape, with a 3.76 ERA and 3.71 FIP entering the series. Chicago’s relief group entered at 4.30 and 4.41, and recent usage around Sean Newcomb, Seranthony Domínguez, and Bryan Hudson adds full-game discomfort.

Royals vs. Rays pick, best bet

Antonacci’s walk-off gave the series its first jolt, Vargas’ homer supplied the second, and Cleveland wasted Parker Messick’s 7.2-inning, 10-strikeout start Tuesday. The Guardians went 0-for-6 with runners in scoring position and left seven men on base. That is harder to absorb when Ramírez, DeLauter, and Martinez are unavailable. Weather adds some late weirdness, with storms in the Chicago forecast, but the side is cleaner than a full-game over. Bibee can pitch well and still give up enough loud contact to lose 5-4.

The best bet is White Sox ML at +104, playable to -105. Chicago has the healthier lineup, better current offense, stronger home form, and more bats matching Bibee’s fastball-heavy shape. Cleveland’s starter and bullpen edge keep the projection tight, which is why the White Sox team hits over 7.5 is the cleanest pivot if listed-pitcher rules get messy. The opener wrinkle also downgrades White Sox F5 ML, because Murphy and Fedde make the early pitching path harder to price. At plus money, though, the full-game side is still the best blend of number and story.

Best bet: White Sox ML (+104).

Final score: White Sox 5, Guardians 4.

Best bet: White Sox (+105) vs. Guardians

Tail it with me in the DKN Betting Group here!