Ciaran Doyle gives his best bet on DraftKings Sportsbook for the 49ers vs. Rams Week 1 matchup.
Published May 14, 2026 8:29 PM EDT
SEATTLE, WASHINGTON - JANUARY 25: Matthew Stafford #9 of the Los Angeles Rams prepares to throw during the NFC Championship NFL football game against the Seattle Seahawks at Lumen Field on January 25, 2026 in Seattle, Washington. (Photo by Kevin Sabitus/Getty Images)
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The opening odds for the San Francisco 49ers vs. Los Angeles Rams Week 1 matchup on Thursday Night Football are now available on DraftKings Sportsbook.
49ers vs. Rams Opening Odds
The Rams open as 2.5-point favorites for this game. They are -155 favorites on the moneyline, while the 49ers are +130 underdogs. The O/U is listed at 48.5 points.
These teams split the regular season series last year, with the road team winning on both occasions. The 49ers won in L.A. in Week 5, 26-23 in OT. In Week 10, the Rams went to San Francisco and got the 42-26 victory.
We’ve got a blockbuster NFC West matchup set for the first Thursday Night Football matchup of the season. Let’s see who comes out on top.
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