Interleague contenders kick off a three-game set Monday night, as the Los Angeles Dodgers host the Tampa Bay Rays at Dodger Stadium.

The Dodgers (45–27, 1st NL West) return home after a 3–3 road trip across Pittsburgh and the south side of Chicago, now looking to rebound against the Rays (41–27, 2nd AL East) behind the surging Shohei Ohtani. 

First pitch is at 10:10 p.m. ET. The Dodgers enter as 1.5-run home favorites with -186 moneyline odds on DraftKings Sportsbook. The Rays are +153 underdogs, with the game total set at O/U 9.5 runs. 

Let’s dive into the top Shohei Ohtani prop bet for Monday’s series opener.

Best Shohei Ohtani Prop Bet on DraftKings Sportsbook

Best Bet: Shohei Ohtani 3+ Hits + Runs + RBIs (+100)

The Rays will see both sides of Shohei Ohtani during their trip to the West Coast, with the two-way superstar — and his MLB-best 1.06 ERA (min. 50 IP) — lined up to start Wednesday’s series finale. But before Tampa Bay can face the National League Cy Young contender, it has to take on the reigning MVP.

After an uncharacteristically quiet start to 2026, the 31-year-old Ohtani has looked every bit like baseball’s most dominant force for more than a month now. Since May 6, the four-time MVP is hitting .366 with eight home runs, 27 RBIs, and 27 runs scored. He leads MLB in OBP (.473), wOBA (.481), OPS (1.140), and wRC+ (212) over that 33-game span.

Ohtani has gone yard in four of his last seven games, raising his season OPS to .975 — tops in the National League. He should keep the momentum rolling against Tampa Bay righty Nick Martinez, who — despite ranking seventh in MLB with a 2.43 ERA this season — has coughed up 11 earned runs compared to only eight strikeouts in his last 18 innings of work. In his last trip to Dodger Stadium in August 2025, Martinez got crushed for four earned runs over 5.1 frames on seven hits (including a home run), two walks, and only three punch-outs.  

Like every game, Ohtani’s fingerprints should be all over Monday’s series opener.