Looking for the best MLB picks today? DraftKings Network analysts share their top bets and predictions for Friday’s slate on DraftKings Sportsbook.

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To see all DraftKings betting analysis, head over to the DraftKings Network sports betting picks page!

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Check out the numerous MLB betting markets available on DraftKings Sportsbook!

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Zach Thompson: Top Home Run Props

Picks below! Read Zach’s full betting analysis here: MLB Best Bets: Top Home Run Props for Friday 4/17/26

Samuel Basallo 1+ Home Run (+610)

Colson Montgomery 1+ Home Run (+397)

Daulton Varsho 1+ Home Run (+501)

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Bryan Armetta: Top NRFI Bets

Picks below! Read Bryan’s full betting analysis here: Best NRFI Bets Today: No Run First Inning MLB Picks For Friday 4/17/26

Orioles vs. Guardians NRFI (-125)

Royals vs. Yankees NRFI (-125)

Tigers vs. Red Sox NRFI (-140)

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Brendan O’Sullivan: Orioles vs. Guardians prediction, pick

Pick below! Read Brendan’s full betting analysis here: Baltimore Orioles vs. Cleveland Guardians prediction, pick for MLB on Friday 4/17/26

Best Bet: Over eight runs (-110)

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Griffin Wong: Tigers at Red Sox prediction, pick

Picks below! Read Griffin’s full betting analysis here: Detroit Tigers at Boston Red Sox prediction, pick for Friday 4/17/26

Best Bet: Boston Red Sox Moneyline (-131)

Strong Lean: Ranger Suárez vs. Casey Mize – Most Strikeouts Thrown: Casey Mize (-131)

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