The Cardinals and Marlins play the final game of their three-game series on Wednesday, April 22.

Miami is a -131 moneyline favorite, while St. Louis is +109 on DraftKings Sportsbook. The game total is set at over/under 8.5 runs.

Let’s get into a pick and prediction for this Cardinals vs. Marlins game.

Cardinals vs. Marlins prediction, preview

The NL Central has five teams above .500. When’s the last time that’s happened? Sure, it’s early in the season, but it’s a surprisingly good start for a few teams. The Cardinals are expected to be one of the weakest teams in the majors this season, but their young core is shining thus far.

Jordan Walker is the obvious standout, but players like JJ Wetherholt, Alec Burleson, Ivan Herrera, Masyn Winn and Nolan Gorman are all contributors in the lineup. Let’s be clear, though, this roster is unlikely to reach the playoffs. It is, however, capable of stringing together wins when the batters are hot.

The pitching hasn’t been terrific, besides closer Riley O’Brien. Kyle Leahy is Wednesday’s starter, posting a 5.21 ERA through 19.0 innings and four starts. He’s allowed 21 hits, 11 earned runs and eight walks while striking out 13 batters this season.

It’s likely the Marlins’ offense capitalizes on this pitching matchup. Miami ranks 13th in runs per game and will need to score to support Janson Junk, who has a 4.50 ERA through 22.0 innings. He’s allowed 23 hits, 11 earned runs and six walks while striking out 15 batters through four starts.

Offense should be at the forefront as neither starter has limited base runners this season.

Cardinals vs. Marlins Pick, Best Bet

Rather than choosing a side, I’m all in for an offensive showing. Both starters are struggling this season, so it will likely come down to who scores more.

Best Bet: Over 8.5 runs (-112)