Quantum Machine Learning (QML) continues to evolve, unlocking new opportunities for diverse applications. In this study, we investigate and evaluate the applicability of QML models for binary classification of genome sequence data by employing various feature mapping techniques. We present an open-source, independent Qiskit-based implementation to conduct experiments on a benchmark genomic dataset. Our simulations reveal that the interplay between feature mapping techniques and QML algorithms significantly influences performance. Notably, the Pegasos Quantum Support Vector Classifier (Pegasos-QSVC) exhibits high sensitivity, particularly excelling in recall metrics, while Quantum Neural Networks (QNN) achieve the highest training accuracy across all feature maps. However, the pronounced variability in classifier performance, dependent on feature mapping, highlights the risk of overfitting to localized output distributions in certain scenarios. This work underscores the transformative potential of QML for genomic data classification while emphasizing the need for continued advancements to enhance the robustness and accuracy of these methodologies.