In this work, we study to release the potential of massive heterogeneous weak computing power to collaboratively train large-scale models on dispersed datasets. In order to improve both efficiency and accuracy in resource-adaptive collaborative learning, we take the first step to consider the \textit{unstructured pruning}, \textit{varying submodel architectures}, \textit{knowledge loss}, and \textit{straggler} challenges simultaneously. We propose a novel semi-asynchronous collaborative training framework, namely ${Co\text{-}S}^2{P}$, with data distribution-aware structured pruning and cross-block knowledge transfer mechanism to address the above concerns. Furthermore, we provide theoretical proof that ${Co\text{-}S}^2{P}$ can achieve asymptotic optimal convergence rate of $O(1/\sqrt{N^*EQ})$. Finally, we conduct extensive experiments on two types of tasks with a real-world hardware testbed including diverse IoT devices.The experimental results demonstrate that $Co\text{-}S^2P$ improves accuracy by up to 8.8\% and resource utilization by up to 1.2$\times$ compared to state-of-the-art methods, while reducing memory consumption by approximately 22\% and training time by about 24\% on all resource-limited devices.