The rapid advancements in machine learning across numerous industries have amplified the demand for extensive matrix-vector multiplication operations, thereby challenging the capacities of traditional von Neumann computing architectures. To address this, researchers are currently exploring alternatives such as in-memory computing systems to develop faster and more energy-efficient hardware. In particular, there is renewed interest in computing systems based on optics, which could potentially handle matrix-vector multiplication in a more energy-efficient way. Despite promising initial results, developing a highly parallel, programmable, and scalable optical computing system capable of rivaling electronic computing hardware still remains elusive. In this context, we propose a hyperspectral in-memory computing architecture that integrates space multiplexing with frequency multiplexing of optical frequency combs and uses spatial light modulators as a programmable optical memory, thereby boosting the computational throughput and the energy efficiency. We have experimentally demonstrated multiply-accumulate operations with higher than 4-bit precision in both matrix-vector and matrix-matrix multiplications, which suggests the system's potential for a wide variety of deep learning and optimization tasks. This system exhibits extraordinary modularity, scalability, and programmability, effectively transcending the traditional limitations of optics-based computing architectures. Our approach demonstrates the potential to scale beyond peta operations per second, marking a significant step towards achieving high-throughput energy-efficient optical computing.