























Abstract:Cardiac muscle tissue exhibits highly non-linear hyperelastic and orthotropic material behavior during passive deformation. Traditional constitutive identification protocols therefore combine multiple loading modes and typically require multiple specimens and substantial handling. In soft living tissues, such protocols are challenged by inter- and intra-sample variability and by manipulation-induced alterations of mechanical response, which can bias inverse calibration. In this work we exploit spatially heterogeneous full-field kinematics as an information-rich alternative to multimodal testing. We recast EUCLID, an unsupervised method for the automated discovery of constitutive models, towards Bayesian parameter inference for highly nonlinear, orthotropic constitutive models. Using synthetic myocardial tissue slabs, we demonstrate that a single heterogeneous biaxial experiment, combined with sparse reaction-force measurements, enables robust recovery of Holzapfel-Ogden parameters with quantified uncertainty, across multiple noise levels. The inferred responses agree closely with ground-truth simulations and yield credible intervals that reflect the impact of measurement noise on orthotropic material model inference. Our work supports single-shot, uncertainty-aware characterization of nonlinear orthotropic material models from a single biaxial test, reducing sample demand and experimental manipulation.
| Subjects: | Tissues and Organs (q-bio.TO); Computational Engineering, Finance, and Science (cs.CE); Machine Learning (cs.LG) |
| Cite as: | arXiv:2510.09498 [q-bio.TO] |
| (or arXiv:2510.09498v3 [q-bio.TO] for this version) | |
| https://doi.org/10.48550/arXiv.2510.09498 arXiv-issued DOI via DataCite |
From: Rogier Krijnen [view email]
[v1]
Fri, 10 Oct 2025 15:59:49 UTC (4,134 KB)
[v2]
Wed, 14 Jan 2026 15:05:54 UTC (3,906 KB)
[v3]
Mon, 4 May 2026 11:55:36 UTC (4,279 KB)
此内容由惯性聚合(RSS阅读器)自动聚合整理,仅供阅读参考。 原文来自 — 版权归原作者所有。