Embodied agents require robust spatial intelligence to execute precise real-world manipulations. However, this remains a significant challenge, as current methods often struggle to accurately position objects in space. Collecting extensive data can help address this issue by enhancing the agent's spatial understanding. Nonetheless, obtaining such data with real robots is prohibitively expensive, and relying on simulation data frequently leads to visual generalization gaps during real-world deployment. To tackle these challenges, we propose ManiBox, a novel bounding-box-guided framework. By decoupling perception from policy generalization, ManiBox effectively reduces the Sim2Real gap, leverages Internet-scale data, and scales our policy data collection in simulation. Specifically, within ManiBox, the RL teacher policy efficiently generates scalable simulation data. The student policy is distilled from this data and takes bounding boxes as input, which is proven sufficient for determining objects' spatial positions, thus enabling zero-shot transfer to real robots. Comprehensive evaluations in both simulated and real-world environments demonstrate that ManiBox exhibits strong spatial generalization and adaptability across various manipulation tasks and settings. Furthermore, our empirical study provides preliminary verification of spatial scaling laws, i.e., the amount of data required for spatial generalization scales with spatial volume following a power-law relationship. At a given spatial volume level, the success rate of manipulation tasks follows Michaelis-Menten kinetics with respect to data volume, exhibiting a saturation effect as data increases. Our videos and code are available at https://thkkk.github.io/manibox