Existing paradigms for ensuring AI safety, such as guardrail models and alignment training, often compromise either inference efficiency or development flexibility. We introduce Disentangled Safety Adapters (DSA), a novel framework addressing these challenges by decoupling safety-specific computations from a task-optimized base model. DSA utilizes lightweight adapters that leverage the base model's internal representations, enabling diverse and flexible safety functionalities with minimal impact on inference cost. Empirically, DSA-based safety guardrails substantially outperform comparably sized standalone models across hate speech classification, detecting unsafe model inputs and responses, and hallucination detection with relative improvements of up to 53% in AUC. Furthermore, DSA-based safety alignment allows dynamic, inference-time adjustment of alignment strength and a fine-grained trade-off between instruction following performance and model safety. Importantly, combining the DSA safety guardrail with DSA safety alignment facilitates context-dependent alignment strength, boosting safety on StrongREJECT by 93% while maintaining 98% performance on MTBench - a total reduction in alignment tax of 8 percentage points compared to standard safety alignment fine-tuning. Overall, DSA presents a promising path towards more modular, efficient, and adaptable AI safety and alignment.